Experimental Myopathies and Muscular Dystrophy: Studies in by Prof. Dr. med. Rainer Heene (auth.)

By Prof. Dr. med. Rainer Heene (auth.)

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Extra resources for Experimental Myopathies and Muscular Dystrophy: Studies in the Formal Pathogenesis of the Myopathy of 2,4-Dichlorophenoxyacetate

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The results of the gelatin film incubations on the whole confirm earlier findings obtained with aqueous incubation media (139), indicating that, histochemically, the activity of muscle phosphorylase is diminished by 2,4-D. , 144). e. a significant decrease of phosphorylase activity in the stalk and leaves of' red beans consequent to local treatment with 2,4-D, have been demonstrated biochemically by NEELY et al. (217). B. Effects of Acute Intoxication in vivo on the Glycogen Metabolism of Skeletal Muscle (avi).

Various stages of longitudinal fibre division could be observed, as a sign of numerical regeneration of muscle fibres. This change is known to occur in muscular dystrophy of man (ERB, cited by (131)), in hypertrophy of normal muscle (DURANTE, cited by (131)), in muscular dystrophy of the mouse (34), and in experimental hypertrophy of the soleus muscle in the rat (129). From the present findings it can be concluded that a thorough cytological restitution of the muscle cell, including the presence of internal nuclei, is a necessary condition of septation and longitudinal fibre division (Fig.

9a-d. Gastrocnemius (svi), serial sections, early stage of myopathy. (a) ~ SDH; (b): glycogen; (c): phosphorylase; (d): UDPGGS. Cytological alterations corresponding to those in Fig. 8d. Decrease in glycogen and in phosphorylase in single 2B/Am fibres, UDPG-GS activity being retained. x 112 2B/~ fibres, show much increased levels of glycogen synthetase. As concluded from the phosphorylase reaction of the entire section, an overall decrease in phosphorylase and glycogen synthetase activities preceding the initial cytological alterations of white muscle fibres (2B/Am) cannot be demonstrated histochemically at this stage of the disease process.

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