Viral Therapy of Human Cancers (Basic and Clinical Oncology) by Joseph G. Sinkovics, Joseph Horvath

By Joseph G. Sinkovics, Joseph Horvath

Surveys attainable study pathways for the remedy of human cancers. Examines the regression of tumors in virally-infected sufferers, in addition to controversies keen on viral oncolysis. Analyzes gene remedy and lively particular immunotherapy of human tumors by way of viral vectors.

Show description

Read or Download Viral Therapy of Human Cancers (Basic and Clinical Oncology) PDF

Best viral books

The Desk Encyclopedia of Microbiology

The table Encyclopedia of Microbiology goals to supply a reasonable and prepared entry to a wide number of microbiological subject matters inside of one set of covers. this convenient desk-top reference brings jointly a very good choice of paintings through the pinnacle scientists within the box. overlaying issues starting from the fundamental technology of microbiology to the present "hot" themes within the box.

Encyclopedia of infectious diseases

This can be nearly a different ebook (encyclopedia of infectious illnesses geared toward the proverbial 'intelligent layman'), and is unusually demanding to discover at the retail marketplace. each one illness access has an creation by way of sections on indicators and diagnostic course, therapies and outlook, and danger elements and preventive measures.

Pulmonary Infection: An Atlas of Investigation and Management

Infections of the lung make up an important percentage of the paintings of the breathing and infectious sickness health professional. Drawing at the illustrative assets of the Edinburgh Royal Infirmary, this fantastically provided atlas offers a visible method of the subject. Dr Hill has chosen quite a number photograph pictures with the intention to permit the person to work out examples of either the infrequent and average manifestations of those problems.

HIV and Young People: Risk and Resilience in the Urban Slum

Revisiting the considering on vulnerability to HIV and possibility of an infection, this ebook offers larger figuring out through contemplating the danger of HIV an infection along notions of non-public and collective resilience, dignity and humiliation.

Additional resources for Viral Therapy of Human Cancers (Basic and Clinical Oncology)

Sample text

In one case, in a female patient, a hemangiosarcoma of the scalp sloughed off after direct inoculation of the PR8 virus; however it regrew and resisted repeated viral inoculations while the patient developed high titers of antibodies, inhibiting viral hemagglutination and neutralizing the virus. The case of another patient (hospital chart on microfilm), whose biopsy-proven hemangiosarcoma regressed during an influenza-like upper respiratory tract infection, remains an anecdote, inasmuch as laboratory proof for the viral infection has not been provided [127].

Instead, tumor cells may allow the virus to complete its full replicative cycle, leading to cell death by burst as the new viral progeny exits. Reovirus-induced apoptotic cell death involves either or both the extrinsic (through cell surface death receptors) and intrinsic (through cytochrome C release from mitochondria) pathways [264]. From modest beginnings—that is, immunologically mediated rejection of murine leukemia–lymphoma cells and tumors by reovirus, as reported in 1976 and 1988 (especially in combination with the nitrosourea BCNU) 48 Sinkovics [265–267]—reoviruses have now advanced to occupy a prominent place among the most respected oncolytic viruses ready for Phase I and II clinical trials.

Its genome is transcribed within the nucleus of the host cell under the direction of its nucleoprotein (NP) [175]. This NP is a multifunctional RNA-binding protein of 498 amino acids with kinase activity. It interacts with the viral RNAdependent RNA polymerase, the viral matrix protein, importins/exportins, export receptor CRM-l, F-actin, and the enzyme helicase. Dendritic cells of the infected host produce interferons, phagocytize apoptotic influenza virus-infected 38 Sinkovics cells, and express the viral antigens to CD4 and CD8 T cells, eliciting a Th1 response in which CD8 T cells secrete IFN␥ and inhibit a Th2 response.

Download PDF sample

Rated 4.43 of 5 – based on 35 votes