Viral Entry into Host Cells by Clare L. Jolly, Quentin J. Sattentau (auth.), Stefan

By Clare L. Jolly, Quentin J. Sattentau (auth.), Stefan Pöhlmann PhD, Graham Simmons PhD (eds.)

For a plague to invade a bunch mobile it must penetrate the actual barrier imposed by means of the plasma membrane. Viruses have advanced really good floor proteins to satisfy this problem. those proteins facilitate supply of the viral genetic info into the host cellphone by way of both fusing the viral envelope with a number telephone membrane or through forming membrane pores. Membrane fusion and pore formation seriously rely on the engagement of host cellphone receptors and receptor selection is a key determinant of viral tropism. The multi-faceted interaction among viral and mobile components in the course of virus access is an interesting box of analysis, that could offer vital perception into viral pathogenesis and outline new objectives for intervention. This booklet presents a finished assessment of this fascinating box of research.

Show description

Read or Download Viral Entry into Host Cells PDF

Similar viral books

The Desk Encyclopedia of Microbiology

The table Encyclopedia of Microbiology goals to supply a reasonable and prepared entry to a wide number of microbiological subject matters inside of one set of covers. this useful desk-top reference brings jointly a superb number of paintings through the pinnacle scientists within the box. overlaying themes starting from the fundamental technology of microbiology to the present "hot" issues within the box.

Encyclopedia of infectious diseases

This is often nearly a special e-book (encyclopedia of infectious illnesses geared toward the proverbial 'intelligent layman'), and is strangely tough to discover at the retail marketplace. every one sickness access has an creation through sections on signs and diagnostic direction, treatment plans and outlook, and possibility elements and preventive measures.

Pulmonary Infection: An Atlas of Investigation and Management

Infections of the lung make up an important share of the paintings of the respiration and infectious ailment health professional. Drawing at the illustrative assets of the Edinburgh Royal Infirmary, this fantastically provided atlas offers a visible method of the subject. Dr Hill has chosen a number photograph pictures in an effort to permit the person to work out examples of either the infrequent and common manifestations of those problems.

HIV and Young People: Risk and Resilience in the Urban Slum

Revisiting the considering on vulnerability to HIV and threat of an infection, this ebook presents larger figuring out by means of contemplating the chance of HIV an infection along notions of private and collective resilience, dignity and humiliation.

Extra info for Viral Entry into Host Cells

Example text

Snyder GA, Ford J, Torabi-Parizi P et al. Characterization of DC-SIGN/R interaction with human immunodeficiency virus type 1 gp120 and ICAM molecules favors the receptor’s role as an antigen-capturing rather than an adhesion receptor. J Virol 2005; 79(8):4589-4598. 84. Stahl-Hennig C, Steinman RM, Tenner-Racz K et al. Rapid infection of oral mucosal-associated lymphoid tissue with simian immunodeficiency virus. Science 1999; 285(5431):1261-1265. 85. Hu J, Gardner MB, Miller CJ. Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells.

A model for the early stages of rotavirus attachment for a neuraminidase-sensitive strain of rotavirus. Initial binding is mediated by the VP8* domain of VP4 that binds to a sialic acid containing glycoprotein or glycolipid, perhaps with a contribution by the underlying galactose. A (possible) conformational change may then occur to facilitate an interaction between the DGE motif in rotavirus VP5* and the I domain of the _2`1 integrin. After this a number of possible additional binding events may take place, involving other integrins and additional receptors, culminating in virus crossing the plasma membrane by a presently unknown mechanism.

J Gen Virol 1991; 72(Pt 5):1131-1137. 11. Trybala E, Liljeqvist JA, Svennerholm B et al. Herpes simplex virus types 1 and 2 differ in their interaction with heparan sulfate. J Virol 2000; 74(19):9106-9114. 12. Gerber SI, Belval BJ, Herold BC. Differences in the role of glycoprotein C of HSV-1 and HSV-2 in viral binding may contribute to serotype differences in cell tropism. Virology 1995; 214(1):29-39. 13. Spear PG. Herpes simplex virus: Receptors and ligands for cell entry. Cell Microbiol 2004; 6(5):401-410.

Download PDF sample

Rated 4.70 of 5 – based on 17 votes