The Molecular Basis of Viral Replication by Milton W. Taylor, Howard V. Hershey (auth.), R. Perez

By Milton W. Taylor, Howard V. Hershey (auth.), R. Perez Bercoff (eds.)

the discovery of the "splicing" of the gene transcripts, the record would come with the full molecular genetics of the lambda bacteriophage, the notions of "promotor," "repressor," and "integration," the invention of the opposite move of genetic info, the very lifestyles of oncogenes, the S'-terminal "cap" strucĀ­ ture of eukaryotic mRNAs, ... Electronmicroscopy, ultracentrifugation and tissue tradition have been the landmarks at the means of the younger technological know-how. in past times few years, notwithstanding, an immense (and now not so silent) revolution happened: recombinant DNA know-how with all its may possibly entered in our laboratories, and restrict mapping of cloned genomes and sequencing gels have changed plaque counting and sucrose gradients. the recent suggestions have made it attainable to "dissect" the complete genome of an outbreak on the molecular point, and reviews that might were dreamt of simply within the mid-seventies grew to become the standard experiments of our days. With new perception into the constitution of viral genomes, and a deeper figuring out of the mechanisms that keep an eye on their expression, our view of viruses was once sure to swap: this quantity bears witness to this remarkable advance.

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The top corner of the VP3 shell domain, between I3B and I3C, is the NIm-III site of HRV14, structurally equivalent to NIm-IA in VP1. RNA-triggered Cleavage of VP21VP4 The capsid protein VPO (the precursor to VP2 and VP4) is cleaved into its components only in the final stages of assembly. G. RossMANN ETAL Figure 3. The fivefold J3-cylinder formed by the amino-terminal ends of VP3 at the pro- tein/RNA interface. Glu-Gly peptides. The proximity of Ser 10 in VP2 to the carboxy-terminus of VP4 suggests that the cleavage of VPO is autoproteolytic.

The north canyon wall is partially lined with the carboxy terminus of VP3. VP2 is hardly associated at all with the canyon, whereas VP1 is the major contributor to the residues lining the canyon. The canyon is 25 A deep and 12-30 A wide. The Immunogenic Sites Because of the additional elaborations which VPl has on the surface relative to VP2 and VP3, its overall shape is that of a kidney (Fig. 6). The first 16 residues of VP1 are not seen in the electron density map. The shell domain of VP1 in HRV14 starts at residue 74.

Nat!. Acad. Sci. USA. 80, 6234-6238. 43) Zimmern, D. (1982) Trends in Biochemical Sciences. 7, 205-207. R. (1985) Cell 42,507-517. 45) Shiba, T. and Saigo, R. (1983) Nature (London) 302, 119-24. H. S. (1986) Proc. Natl. Acad. Sci. USA. 83, 2531-2535. 47) Summers, J. S. (1982) Cell 29, 403-415. , Schuster, P. Winkler-Oswatisch, R. (1981) Sci. Am. 244, 88-118. C. (1979) Nature (London) 288,598-600. , & Weissman, C. (1978) Cell 13, 735-744. M. (1974) Virology 61,458-73. M. (1977) Virology 80,336-46.

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