The Artery and the Process of Arteriosclerosis: Pathogenesis by Dr. John French (auth.), Stewart Wolf (eds.)

By Dr. John French (auth.), Stewart Wolf (eds.)

The current quantity includes the 1st half the edited tran­ script of a six-day convention, "Fundamental facts on Reactions of Vascular Tissue in Man," held April 19-25, 1970, in Lindau, West Germany. the rest of the court cases, facing the epide­ miologic, scientific and preventive facets of arteriosclerosis, may be released in a moment quantity. The convention was once held less than the auspices of the foreign Society of Cardiology, the overseas Cardiology origin and the ecu Atherosclerosis team. the purpose of the convention used to be to accomplish a synthesis of current wisdom referring to arterioscle­ rosis. for this reason, staff have been introduced jointly from a number of coun­ attempts and from numerous disciplines that don't mostly intercom­ municate at no cost trade of knowledge and ideas. Six huge topic parts have been brought through unmarried papers; 3 of them are integrated during this quantity. within the dialogue which each one formal pres­ entation, the contributors tried to reconcile disparate info and interpretations and to arrive .a transparent identity of significant components of lack of know-how and of the most important questions for destiny learn. The layout of the complaints doesn't keep on with accurately that of the convention itself. The formal papers are incorporated, a little bit ab­ breviated, and excerpts of the dialogue were accumulated below a chain of themes prepared in logical series. hence, the quoted statements don't inevitably look so as or within the position within the software the place they have been made. vital concerns, syntheses and unanswered questions are interspersed one of the issues as edi­ torial comments.

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Additional resources for The Artery and the Process of Arteriosclerosis: Pathogenesis The first half of the Proceedings of an Interdisciplinary Conference on Fundamental Data on Reactions of Vascular Tissue in Man April 19–25, 1970, Lindau, West Germany

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GILLMAN: We did not measure blood pressures. , 1960). COMMENT Dr. Gillman showed slides of ruptured internal elastic lamina in human renal and mesenteric muscular arteries associated with finer "reduplicated" elastic lamina. , 1955; Gillman, 1959) led him to postulate a difference between "true" and "pseudo" elastic lamina in diseased arteries, a difference similar to that observed in the elastic material of human dermis injured by ultraviolet irradiation and in the tunica propria of human cholesterolic gall bladders.

FREMONT-SMITH: I should like to point out in this connection of normality and pathology, that any infant is born with a great many dead glomeruli. Now this is normal, because every infant has it, ARTERIAL STRUCTURE AND FUNCTION but the glomerulus which is dead is not a normal glomerulus, and therefore the difference between normal and pathological is academic. It may not be appropriate for us to make such a distinction. 29 30 CHAPTER 1 FIGURE 1. Light microscopic appearance of an aorta from a twelveweek-old human fetus .

Electron micrograph of tissue fixed in glutaraldehyde, post-fixed in osmium tetroxide, embedded in Epon-8l2, and stained with uranyl acetate and lead citrate. Aortic medial cells in a l5-week-old human fetus. Elastic units (arrows) consisting of a central homogeneous core surrounded by micro fibrils fuse to form larger elastic elements. Note that the two smooth muscle cells have many pinocytotic vesicles, prominent mitochondria, and conspicuous, dilated profiles of rough-surfaced endoplasmic reticulum with finely filamentous and granular content; magnficiation = x 42,000.

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