Selective serotonin reuptake inhibitors past, present, and by S. Clare Stanford

By S. Clare Stanford

The SSRIs have had an important effect at the therapy of melancholy and one, Prozac, has even attained cult prestige. but, their predecessors are nonetheless used with impunity and we haven't any definitive reason for their healing results. In reviewing the validated and novel symptoms for remedy with those medications, SSRIs: previous, current and destiny, includes a frank and targeted appraisal in their defense, efficacy and tolerability in addition to exploring their underlying neurobiology.

This publication is particularly designed to be available and instructive to either scholars and specialists within the medical and preclinical sciences. each time possible, person chapters combine fabric from those components and so they all commence by way of outlining the history to every subject prior to discussing extra really good study. for that reason, readers who're devoted to one in every of department of this box could be inspired to extend their figuring out of, and curiosity in, others.

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Psychopharmacol Bull 1997; 33:659-665. 92. Özdemir V, Naranjo CA, Herrmann N et al. The extent and determinants of changes in CYP2D6 and CYP1A2 activities with therapeutic doses of sertraline. J Clin Psychopharmacol 1998; 18:55-61 CHAPTER 3 SSRIs in Depression: Distinctive Actions? Julie Newman and Andrew A. Nierenberg T he introduction of the selective serotonin reuptake inhibitors (SSRIs) has radically changed the treatment of depression worldwide. The five currently marketed SSRIs, fluoxetine, sertraline, paroxetine, fluvoxamine and citalopram were accepted by international regulatory agencies because these medications were found to be superior to placebo and, at least for most clinical populations, of equal efficacy when compared to the older generations of tricyclic antidepressants (TCAs).

Kurtz DL, Bergstrom RF, Goldberg MJ et al. The effect of sertraline on the pharmacokinetics of desipramine and imipramine. Clin Pharmacol Ther 1997; 62:145-156. 88. Sproule BA, Otton SV, Cheung SW et al. CYP2D6 inhibition in patients treated with sertraline. J Clin Psychopharmacol 1997; 17:102-106. 89. Özdemir V, Naranjo CA, Herrmann N et al. Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo. Clin Pharmacol Ther 1997; 62:334-347.

Lemberger L, Bergstrom RF, Wolen RL et al. Fluoxetine: Clinical pharmacology and physiologic disposition. J Clin Psychiatry 1985; 46:14-19. 28. Aronoff GR, Bergstrom RF, Pottratz ST et al. Fluoxetine kinetics and protein binding in normal and impaired renal function. Clin Pharmacol Ther 1984; 36:138-144. 29. Spigset O, Granberg K, Hägg S et al. Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms. Eur J Clin Pharmacol 1997; 52:129-133. 30. DeVane CL, Gill HS.

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