Selective serotonin reuptake inhibitors past, present, and by S. Clare Stanford

By S. Clare Stanford

The SSRIs have had an important effect at the therapy of melancholy and one, Prozac, has even attained cult prestige. but, their predecessors are nonetheless used with impunity and we haven't any definitive reason for their healing results. In reviewing the validated and novel symptoms for remedy with those medications, SSRIs: previous, current and destiny, includes a frank and targeted appraisal in their defense, efficacy and tolerability in addition to exploring their underlying neurobiology.

This publication is particularly designed to be available and instructive to either scholars and specialists within the medical and preclinical sciences. each time possible, person chapters combine fabric from those components and so they all commence by way of outlining the history to every subject prior to discussing extra really good study. for that reason, readers who're devoted to one in every of department of this box could be inspired to extend their figuring out of, and curiosity in, others.

Show description

Read Online or Download Selective serotonin reuptake inhibitors past, present, and future PDF

Similar neurology books


Have you visible whatever that wasn't fairly there? Heard an individual name your identify in an empty condo? Sensed somebody following you and circled to discover nothing?

Hallucinations don’t belong fully to the insane. even more more often than not, they're associated with sensory deprivation, intoxication, disease, or harm. individuals with migraines might even see shimmering arcs of sunshine or tiny, Lilliputian figures of animals and folks. individuals with failing eyesight, satirically, could develop into immersed in a hallucinatory visible international. Hallucinations could be as a result of an easy fever or perhaps the act of waking or falling asleep, while humans have visions starting from luminous blobs of colour to fantastically designated faces or terrifying ogres. those people who are bereaved may well obtain comforting “visits” from the departed. In a few stipulations, hallucinations may end up in spiritual epiphanies or perhaps the sensation of leaving one’s personal physique.

Humans have consistently sought such life-changing visions, and for hundreds of thousands of years have used hallucinogenic compounds to accomplish them. As a tender health professional in California within the Sixties, Oliver Sacks had either a private and a pro curiosity in psychedelics. those, with his early migraine reports, introduced a lifelong research into the different types of hallucinatory event.

Here, together with his traditional attractiveness, interest, and compassion, Dr. Sacks weaves jointly tales of his sufferers and of his personal mind-altering stories to light up what hallucinations let us know concerning the association and constitution of our brains, how they've got encouraged each culture’s folklore and artwork, and why the potential of hallucination is found in us all, an integral part of the human situation.

Paediatric Neurology in Clinical General Practice: Common Neurological Problems in General Pediatrics

The final pediatrician faces an array of medical conditions in scientific perform. This quantity is meant to relieve questions on one region the overall pediatrician faces: universal neurological difficulties. Emphasizing the problems that this type of practitioner might face in daily perform, instead of infrequent or strange stipulations, this ebook describes find out how to continue with the medical exam, prognosis and administration of neurological difficulties in teenagers.

Additional info for Selective serotonin reuptake inhibitors past, present, and future

Example text

Psychopharmacol Bull 1997; 33:659-665. 92. Özdemir V, Naranjo CA, Herrmann N et al. The extent and determinants of changes in CYP2D6 and CYP1A2 activities with therapeutic doses of sertraline. J Clin Psychopharmacol 1998; 18:55-61 CHAPTER 3 SSRIs in Depression: Distinctive Actions? Julie Newman and Andrew A. Nierenberg T he introduction of the selective serotonin reuptake inhibitors (SSRIs) has radically changed the treatment of depression worldwide. The five currently marketed SSRIs, fluoxetine, sertraline, paroxetine, fluvoxamine and citalopram were accepted by international regulatory agencies because these medications were found to be superior to placebo and, at least for most clinical populations, of equal efficacy when compared to the older generations of tricyclic antidepressants (TCAs).

Kurtz DL, Bergstrom RF, Goldberg MJ et al. The effect of sertraline on the pharmacokinetics of desipramine and imipramine. Clin Pharmacol Ther 1997; 62:145-156. 88. Sproule BA, Otton SV, Cheung SW et al. CYP2D6 inhibition in patients treated with sertraline. J Clin Psychopharmacol 1997; 17:102-106. 89. Özdemir V, Naranjo CA, Herrmann N et al. Paroxetine potentiates the central nervous system side effects of perphenazine: Contribution of cytochrome P4502D6 inhibition in vivo. Clin Pharmacol Ther 1997; 62:334-347.

Lemberger L, Bergstrom RF, Wolen RL et al. Fluoxetine: Clinical pharmacology and physiologic disposition. J Clin Psychiatry 1985; 46:14-19. 28. Aronoff GR, Bergstrom RF, Pottratz ST et al. Fluoxetine kinetics and protein binding in normal and impaired renal function. Clin Pharmacol Ther 1984; 36:138-144. 29. Spigset O, Granberg K, Hägg S et al. Relationship between fluvoxamine pharmacokinetics and CYP2D6/CYP2C19 phenotype polymorphisms. Eur J Clin Pharmacol 1997; 52:129-133. 30. DeVane CL, Gill HS.

Download PDF sample

Rated 4.28 of 5 – based on 24 votes