Rickettsial Infection and Immunity (Infectious Agents and by Burt Anderson, Herman Friedman, Mauro Bendinelli

By Burt Anderson, Herman Friedman, Mauro Bendinelli

As a gaggle, rickettsiae, and similar micro organism, comprise a bunch of human pathogens that experience lately named as motives of `emerging diseases'. This certain quantity deals an intensive and present overview of info at the pathogenesis and immune reaction elicited through memebers of the genera Rickettsia, Ehrlichia, Coxiella, Orlentia, and Bartonella, in contributions authored via the specialist clinicians and researchers who paintings with those organisms.

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On the other hand, there are study results that show that pretreatment of rickettsiae with immune sera or monoclonal antibodies46 prevents infection or reduces infectivity. From these data it could be suggested IMMUNITY TO RICKETTSIAE 21 that antibody is important in secondary immune responses to these organisms by binding the organisms to prevent attachment or penetration of the host cell by the organisms, which is analogous to the function of secretory IgA in resistance to secondary infections of the gastrointestinal mucosa by S.

Immun. 61: 1926-1935. 3 Cytokines Influencing Infections by Rickettsia Species JENIFER TURCO and HERBERT H. WINKLER 1. INTRODUCTION The genus Rickettsia is a group of obligate intracellular bacteria that grow (both in nature and in the laboratory) only within vertebrate or arthropod cells. Unlike many other intracellular bacteria, intracellular rickettsiae are not separated from the cytoplasm of their host cells by the membranes of vacuoles (phagosomes or phagolysosomes). Rather, rickettsiae grow within the cytoplasm of their host cells with host cell cytoplasm immediately outside their own surface layers.

Med. 157: 974-986. 55. Wisseman, C. , and Waddell, A,, 1983, Interferon-like factors from antigen- and mitogenstimulated human leukocytes with antirickettsial and cytolytic actions on Rickettsia prowazekii. Infected human endothelial cells, fibroblasts, and macrophages, J. Exp. Med. 157: 1780-1793. 56. , and Winkler, H. , 1983, Comparison of the properties of antirickettsial activity and interferon in mouse lymphokines, Infect. Immun. 42: 27-32. 57. , Thompson, H. , and Winkler, H. , 1984, Interferon-γ inhibits the growth of Coxiella burnetii in mouse fibroblasts, Infect.

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