Protozoans in Macrophages by Eric Denkers

By Eric Denkers

Utilizing as a subject the come across among protozoan parasites and macrophages, this quantity brings jointly cellphone biologists, immunologists and protozoologists to check present advancements during this large and dynamic study zone. mentioned are methods protozoans determine their intracellular area of interest, how they turn on macrophage effector features, what those capabilities are, and ability wherein a number of protozoans subvert macrophage task. What emerges is an image of the macrophage as a key mobilephone style within the host reaction to protozoan an infection. How those cells reply, and the way their responses might be subverted, usually are serious determinants within the end result of protozoan an infection. hundreds of thousands of lives are misplaced each year to protozoan infections, most significantly these because of Plasmodium, but additionally Trypanosoma and Leishmania spp. different protozoans, comparable to Toxoplasma, are so exquisitely tailored to their host that they hardly ever reason affliction, other than in the course of host immunodeficiency. we are hoping that via practising an knowing of the biology of protozoans in macrophages we are going to finally be capable to treating and fighting affliction and mortality attributable to this significant type of microbial pathogens.

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As discussed below, the phagocytes engulf (apoptotic or necrotic) through the engagement of scavenger receptors, eventually turning into safe shelters for T. cruzi growth. As mentioned, the extravasation of plasma proteins to peripheral tissues is one of the earliest manifestations of inflammation. , components of the complement and kallikrein-kinin systems. 96 The possibility that C1q-sensitized parasites are internalized by macrophages via CD91 remains to be assessed. 97 It is unknown if these suppressive effects may occur when CD91-bearing macrophages simultaneously internalize apoptotic cells and C1q-decorated parasites.

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Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins. Molec Biol Cell 2002; 13:2397-2409. 52. Schwab JC, Beckers CJM, Joiner KA. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve. Proc Natl Acad Sci USA 1994; 91:509-513. 53. Hunter CA, Reichmann G. Immunology of toxoplasma infection. In: Joynson DH, Wreghitt TJ, eds. Toxoplasmosis: A Comprehensive Clinical Guide. Cambridge University Press, 2001:43-57.

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