Principles of Molecular Virology by Alan J. Cann

By Alan J. Cann

The 5th version of the hugely winning Principles of Molecular Virology takes on a molecular method of the reason of virology, providing easy in a transparent, concise and student-friendly demeanour. This absolutely up to date undergraduate textual content explores and explains the elemental features of virology, together with constitution of virus debris and genome, replication, gene expression, an infection, pathogenesis and subviral brokers. an internet site with self-assessment questions and different assets aids in pupil knowing.

  • Completely rewritten and updated
  • Clear and straightforward to understand
  • Examples overlaying vital principles in virology
  • All new illustrations
  • Accompanying site with interactive assets and instructing fabric for instructors

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Example text

In common with most enveloped viruses, the nucleocapsid is surrounded by an amorphous layer with no visible structure that interacts with both the core and the overlying lipid envelope, linking them together. This is known as the matrix. The matrix (M) protein is usually the most abundant protein in the virus particle; for example, there are approximately 1800 copies of the M protein, 1250 copies of the N protein, and 400 G protein trimers in VSV particles. The lipid envelope and its associated proteins are discussed in more detail later.

The g8p subunits in successive turns of the helix interlock with the subunits in the turn below and are tilted at an angle of approximately 20 to the long axis of the particle, overlapping one another like the scales of a fish. 5 nm. Because the phage DNA is packaged inside the core of the helical particle, the length of the particle is dependent on the length of the genome. 5 phage genome length of DNA), and maxiphage (genetically defective forms but containing more than one phage genome length of DNA) occur.

The core is composed of a tightly compressed nucleoprotein, and the double-stranded DNA genome is wound around it. , the use of vaccinia virus to immunize against smallpox [variola] virus). Poxviruses and a number of other complex viruses also emphasize the true complexity of some virusesdthere are at least ten enzymes present in poxvirus particles, mostly involved in nucleic acid metabolism/genome replication. Poxviruses are among the most complex particles known. They are at one end of the scale of complexity and are included here as a counterbalance to the descriptions of the simpler viruses given earlier.

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