By C.A. Bruggeman, H.W. Doerr, A. Ramon, M. Scholz
Specified subject factor: Intervirology 1999, Vol. forty two, No. 5-6 This precise factor includes contributions by way of prime scientists and clinicians within the box of CMV, who participated within the 2d Symposium on CMV-Related Immunopathology, held in Maastricht, Netherlands, in September 1999. contemporary learn has proven that cytomegalovirus manipulates the immune process in an evidently 'intelligent' approach to advertise virus patience, replication and dissemination. This manipulation results in aberrant host immune responses and to sickness in immunocompromised folks resembling transplant recipients or AIDS sufferers. notwithstanding, there's transforming into proof that CMV-related immunopathomechanisms can also be of importance in grownup non-immunocompromised humans, even within the absence of detectable viremia. Reflecting and reading the main up to date info to be had on CMV-related immunopathology and anti-CMV treatment, this booklet should be of significant curiosity for clinicians occupied with the analysis and remedy of CMV infections in addition to for researchers engaged on herpesvirus biology and the improvement of antiviral medicines.
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Extra resources for Novel Immunological Aspects of CMV-Related Diseases: Pathogenesis, Diagnosis and Therapy (Intervirology, 5-6)
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Immunopathology Immune Escape and Reactivation Intervirology 1999;42:314–321 Human Cytomegalovirus Latency and Reactivation – A Delicate Balance between the Virus and Its Host’s Immune System Cecilia Söderberg-Nauclér a Jay A. , USA Key Words Cytomegalovirus W Macrophages W Latency W Reactivation W Allogeneic stimulation Abstract Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that still causes severe morbidity and mortality in immunocompromised individuals. During its evolution, the virus has developed sophisticated methods to evade immune recognition and to establish life-long persistence in its host.
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