New Treatment Strategies for Dengue and Other Flaviviral by Novartis Foundation

By Novartis Foundation

Книга New remedy innovations for Dengue and different Flaviviral illnesses New therapy thoughts for Dengue and different Flaviviral DiseasesКниги Медицина Автор: Novartis origin Год издания: 2006 Формат: pdf Издат.:Wiley Страниц: 276 Размер: 6,6 ISBN: 0470016434 Язык: Английский0 (голосов: zero) Оценка:Dengue virus is a member of the Flaviviridae relations, including viruses linked to human illnesses comparable to yellow fever, jap encephalitis and hepatitis C. Dengue fever is transmitted via mosquitoes, largely Aedes aegypti. There are 4 serotypes of dengue virus, of which DENV-2 has been the main commonplace in lots of fresh epidemics. Following basic an infection, lifelong immunity develops, combating repeated attack through an identical serotype. despite the fact that, the non-neutralizing antibodies from a prior an infection or maternally got antibodies are inspiration to shape complexes with a special serotype in the course of a next an infection and reason dengue haemorrhagic fever/dengue surprise syndrome, which are deadly. there is not any therapy or vaccine on hand this present day that could strive against this rising and out of control disorder. This ebook good points contributions from the world’s top researchers engaged on dengue and similar flaviviruses who study the present state-of-the-art within the molecular biology of the dengue virus. specific emphasis is put on the constitution and serve as of the virus and the focusing on of virus proteins via strength antiviral brokers. The pathogenesis of dengue and dengue haemorrhagic fever are mentioned intimately, in particular the objective cells and the categorical receptors on those cells, thereby constructing a transparent review of host and viral elements that give a contribution to dengue haemorrhagic fever. eventually, the ebook experiences the healing ideas, paying specific realization to ways that vector, host and setting can play a severe function within the unfold of this illness. With dengue fever and different rising viral illnesses changing into more and more ordinary all over the world, this publication offers helpful perception into the virus that motives this ailment and capability how one can deal with it. it really is crucial interpreting for all these operating in tropical illnesses, public wellbeing and fitness and virology.

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Sample text

Gubler: Martin Hibberd, you have done some sequencing of the current epidemic: is it DENV-1? Hibberd: I wish I could answer that question. We have sequences from Indonesia and Malaysia. Gubler: I hope you are doing the whole genome and not just the envelope. Hibberd: We are doing the whole genome and we have a supply coming through. Halstead: We don’t know what the herd immunity for dengue is. Singapore isn’t very relevant because there are 99% susceptible individuals. Your epidemic isn’t controlled by herd immunity but opportunism—a viraemic transient finds a home with Ae.

M. Paranjape and E. Harris, unpublished results), based on studies with the flaviviruses WNV, KUN, JEV and DENV. Mutations in the 3′SL reduce translation of DENV reporter RNAs and replicons (Holden & Harris 2004, Holden et al 2006) and negatively impact flavivirus replication and viability (Blackwell & Brinton 1997, Men et al 1996, Tilgner et al 2005, Zeng et al 1998). Additional conserved sequence motifs and predicted secondary structures are found along the length of the flavivirus 3′ UTR (Olsthoorn & Bol 2001, Proutski et al 1997) that play a role in flaviviral RNA synthesis (Alvarez et al 2005b, Lo 26 HARRIS ET AL et al 2003, Tilgner & Shi 2004).

The DENV-2 reporter replicon was transcribed in vitro and trans- FLAVIVIRUS MOLECULAR BIOLOGY 31 A B FIG. 3. Schematic diagrams of the targeted locations in the DENV 5′- and 3′-UTRs. (A) Locations of P-PMO target sequences in the DENV-2 5′ UTR. Indicated by lines are target sequences for the DENV 5′SL P-PMO and the 5′ AUG P-PMO. The predicted secondary structure of the DENV-2 5′ UTR was determined using the mFold web server (Zuker 2003). (B) Locations of P-PMO target sequences in the DENV 3′ UTR.

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