Neurosteriods: A New Regulatory Function in the Nervous by Etienne-Emile Baulieu

By Etienne-Emile Baulieu

Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of wonderful scientists and scientific researchers exhaustively and severely assessment all aspects of neurosteroids fascinated by habit, rigidity, reminiscence, melancholy, nervousness, getting older of the mind, and neurodegenerative ailments. those participants remove darkness from the function of neurosteroids in mind improvement and plasticity and element their neuromodulatory effect on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. in actual fact pointing the best way towards novel pharmaceutical brokers that could be of important healing worth, relatively with reference to getting older psychological services, Neurosteroids: a brand new Regulatory functionality within the apprehensive process bargains neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the 1st accomplished, state of the art evaluate of those vital bioactive molecules.

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Extra info for Neurosteriods: A New Regulatory Function in the Nervous System (Contemporary Endocrinology)

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Cognitive abilities exhibit a natural decline with age, although with considerable interindividual differences, which have been exploited in the search for relationships between the performance of each approx 2-yr-old rat and PREG S content in several areas of its brain, particularly in the hippocampus (113). The spatial memory performances of aged rats were investigated in two different spatial memory tasks, the Morris water maze and the Y maze. Performances in both tests were correlated and, accompanied by appropriate controls, were considered to evaluate genuine memory function.

Purification of the proteins and cloning of the cDNAs encoding these proteins has rigorously demonstrated that these activities indeed reside within single proteins. The synthesis of neurosteroids probably proceeds through pathways both similar to and different from those used in the adrenals, gonads, and placenta. The brain contains additional steroid metabolizing enzymes that convert classic steroid hormones to a variety of neuroactive compounds, shown in Fig. 2. Pregnenolone (PREG), dehydroeplandrosterone (DHEA), and metabolites of progesterone (PROG) and 20_ hydroxyprogesterone have been identified in the brains of many species.

The spatial memory performances of aged rats were investigated in two different spatial memory tasks, the Morris water maze and the Y maze. Performances in both tests were correlated and, accompanied by appropriate controls, were considered to evaluate genuine memory function. , these rats with no or minimal memory deficits had the highest PREG S levels, whereas no relationship was found with PREG S content in other brain areas (amygdala, prefrontal cortex, parietal cortex, striatum). As a confirmation for the role of PREG S, the memory deficit of cognitively impaired aged rats was transiently corrected after either intraperitoneal or bilateral intrahippocampal injection of PREG S.

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