By Antonio V. Delgado-Escueta, Renzo Guerrini MD, Marco T. Medina MD, Pierre Genton MD, Michelle Bureau MD, Charlotte Dravet MD
This quantity is the 1st accomplished textual content and scientific reference on idiopathic myoclonic epilepsies of infancy, early life, youth, and maturity. The world’s most well known specialists describe the phenotypes and subtypes of myoclonic epilepsies and the underlying molecular defects and summarize state of the art advances in molecular genetics that shed new mild at the etiologies of those syndromes. The ebook bargains clinicians much-needed assistance in spotting and diagnosing idiopathic myoclonic epilepsies and choosing applicable therapy. every one bankruptcy contains diagnostic and remedy algorithms to steer practitioners in medical choice making.
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Additional resources for Myoclonic Epilepsies (Advances in Neurology)
Genton. In: Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi M, eds. Idiopathic generalized epilepsies. London: John Libbey, 1994:229â 251). 6. Castells C, Mendilaharsu C. La epilepsia mioclÃ³nica bilateral y consciente. Acta Neurol Latinoamer 1958;4:23â 48. 7. Gastaut H, RÃ©mond H. Etude Ã©lectroencÃ©phalographique des myoclonies. Rev Neurol (Paris) 1952;86:596â 609. 8. Gastaut H. â Benignâ of â Functionnalâ (versus â Organicâ ) epilepsies in different stages of life: an analysis of the corresponding age-related variations in the predisposition to epilepsy.
The frequency of flashes that is effective in triggering this response is usually between 8 and 20 Hz. Patients present with rapid myoclonic jerking of the periorbital muscles producing fluttering of the eyelids and blinking, which is synchronous with the flashes. There may be vertical oscillations of the eyeballs. Amplitude of the response increases progressively during the first flashes, reaching a maximum within a few seconds. The maximal amount of muscle activity is initially observed in the inferior orbicularis oculi muscles with subsequent irradiation to other facial muscles, the frontal and occipital areas, and the neck (52).
The latency between electric stimulation (median nerve) and onset of reflex myoclonus is 65 Â± 5 msec when the recording is made from the abductor pollicis brevis (APB) muscle. Topographic mapping of the SEP voltage shows, for the P30 component, a field distribution very similar to that of the premyoclonic potential. The CRT has a duration of 28 Â± 4 msecâ a value that is three- to four-fold higher than that observed in PMEs (34). It is, therefore, probable that in Rett syndrome the following sequence of events occurs: slight delay in central conduction of the impulse afferent to the sensorimotor cortex (N20), slowing of the processing of the afferent impulse (interval N20â P30; mean = 11 msec), delay in corticocortical transmission to the precentral neurons subserving movement of the stimulated body segment (latency increase P30-C-reflex; mean = 32 msec), and rapid descending volley to the spinal motoneurons.