Multiple Sclerosis Therapeutics by Jeffrey A. Cohen, Richard A. Rudick

By Jeffrey A. Cohen, Richard A. Rudick

This e-book comprehensively studies the present country of medical trial equipment in a number of sclerosis therapy, delivering investigators, sponsors and experts with present wisdom of final result measures and research designs for disorder and symptom administration. The prestige of the swiftly evolving box of disease-modifying medications is gifted, with emphasis at the such a lot promising remedies at present being proven. specialists speak about sickness and symptom administration for MS subtypes, together with neuromyelitis optica and pediatric MS. moreover, key medical advances in MS pathology, genetics, immunology and epidemiology are awarded. The fourth version has been commonly revised, that includes greater than 50% new fabric. All chapters were considerably up-to-date to supply present info on quickly evolving themes and this quantity includes 15 new chapters, reflecting the expansion of the sector in recent times. This publication is an important reference for practitioners taking good care of MS sufferers, investigators making plans or carrying out scientific trials, and scientific trial sponsors.

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Pathology of Multiple Sclerosis. In Cook S, eds. Handbook of Multiple Sclerosis. Marcel Dekker, 2001; 289–324. 4. Stadelmann C, Albert M, Wegner C, Bruck W. Cortical pathology in multiple sclerosis. Curr Opin Neurol 2008; 21: 229–34. 5. Bakshi R, Thompson AJ, Rocca MA, et al. MRI in multiple sclerosis: current status and future prospects. Lancet Neurol 2008; 7: 615–25. S14746. De SN, Filippi M. MR spectroscopy in multiple sclerosis. J Neuroimaging 2007; 17 Suppl 1: 31S–5S. 7. Tartaglia MC, Arnold DL.

Dabu-Bondoc S, Franco S. Risk-benefit perspectives in COX-2 blockade. Curr Drug Saf 2008;3(1):14–23. 84. Woodcock J, Sharfstein JM, Hamburg M. S. Food and Drug Administration. N Engl J Med 2010;363(16):1489–91. 11 Section I Chapter 2 Introduction The pathology of multiple sclerosis Ranjan Dutta and Bruce D. Trapp Introduction Descriptions of putative MS date back as early as the Middle Ages, but it was in the nineteenth century when MS was definitively recognized as a distinct disease. 1 He examined a young woman who presented with tremor, slurred speech, and abnormal eye movements.

Axonal atrophy precedes axonal degeneration in MAG-deficient mice. 29 In PLP- and CNP-null mice, axonal swelling precedes axonal degeneration. 32 PLP-null mice also have alterations in compact myelin membrane spacing. 33 While the MAG- and CNP-null mice segregate the role of oligodendrocytes in myelin formation and axonal survival, the mechanisms by which these proteins provide this support are currently unknown. If removal of single myelin proteins can cause axonal degeneration without affecting the structure of myelin, it should not be surprising that loss of myelin in MS can cause axonal degeneration.

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