Molecular Oncology. Principles and recent advances by Camacho J. (ed.)

By Camacho J. (ed.)

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Cadmium is a potent human carcinogen in occupational exposure scenarios and it has been associated with lung, prostate, pancreas and kidney cancers [45]. Arsenic Arsenic is well known as a poison, and it is a carcinogen in humans. Many studies have confirmed the generation of free radicals during arsenic metabolism in cells. ROS generation can cause cell damage and death through activation of oxidative sensitive signaling pathways [48]. Arsenic-mediated generation of ROS is a complex process that involves the generation of a variety of ROS including superoxide, singlet oxygen, peroxyl radical, nitric oxide, hydrogen peroxide, dimethylarsinic peroxyl radical and dimethylarsinic radical.

The historical perspective on the development of the estrogen-cancer association from early observations to recent conclusive reports began in 1896 with the Beatson report that ovary removal gives remission of breast cancer (Beatson Lancet 1896) [6]. However, the first time estrogen use was linked to endometrial cancer was in 1979 (Cramer OG 1979) [7]. In 1980, the effects of estriol on mammary carcinomas were debated (Lemon AES 1980) [8] (Bradlow JE 1996) [9]. In 1985, estrogen was reported to be a cause of endometrial cancer and likely a factor in breast cancer (Persson AOGSS 1985) [10].

Brit J Cancer 1992; 66: 888-92. Cantor KP, Ward MH, Moore L, Lubin J. Water contaminants. , Fraumeni Jr. F. (Eds). Cancer epidemiology and prevention, third ed. Kluwer Academic Publisher. Dondrecht, pp. 149-69. Witkiewicz-Kucharczyc A, Bal W. Damage of zinc fingers in DNA repair proteins, a novel molecular mechanism in carcinogenesis. Toxicol Lett 2006; 162: 29-42. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Nicohem 2004; 266: 37-56.

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