Metal-Based Neurodegeneration: From Molecular Mechanisms to by Robert Crichton, Roberta Ward

By Robert Crichton, Roberta Ward

Neurodegenerative ailments of the human mind look in numerous kinds, leading to problems of stream and coordination, cognitive deterioration and psychiatric disturbances. the various key elements resulting in neurodegenerative ailments are related, together with the disorder of steel ion homeostasis, redox-active steel ions producing oxidative rigidity, and intracellular inclusion bodies.

Metal-based Neurodegeneration provides a close survey of the molecular origins of neurodegenerative illnesses. every one bankruptcy is devoted to a selected sickness, proposing the newest medical findings,  together with info in their biochemical actors (proteins or peptides), their common and pathological conformations, and an outline of the ailments features, with an emphasis at the function of metal-induced oxidative rigidity, which can lead to the construction of intracellular aggregates of aim proteins and peptides. 

Topics lined include:

  • Brain functionality, body structure and the blood-brain barrier
  • Immune approach and neuroinflammation
  • Aging and gentle cognitive impairment, MCI
  • Parkinson’s Disease
  • Alzheimer’s Disease
  • Creutzfelt-Jakob and comparable prion diseases
  • Alcoholic mind Damage
  • Therapeutic ideas to strive against the onset and development of neurological diseases

This widely up to date, complete color, moment version of Metal-based Neurodegeneration is a vital textual content for study scientists and clinicians operating in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

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Neurochem. , 33, 2472–2479. R. T. (2012) Parkinson’s disease and the immune system, in Mechanisms in Parkinson’s Disease: Models and Treatments (ed. J. Dushanova), InTech. 1 Introduction – The Importance of Metal Ions in Brain Function Organic molecules, based on the elements C, H, N and O, such as amino acids, carbohydrates, lipids and their constituent fatty acids, purines and pyrimidine bases and the polymers made out of them, proteins, polysaccharides and the nucleic acids RNA and DNA, are extremely important for living organisms.

However, as we will see in later chapters, the presence of any of these redox-active metals in excess within localized regions of the central nervous system (CNS) frequently spells disaster, with associated neurodegeneration. 2 Sodium, Potassium and Calcium Channels and Pumps Nerve impulses consist of a wave of transient membrane depolarization/re-polarization which traverses the nerve cell and is designated an action potential. In their Nobel Prize-winning studies1 to uncover the ionic mechanism of action potentials, Alan Hodgkin and Andrew Huxley carried out experiments on the giant axon of the squid (Hodgkin and Huxley, 1952).

What is most striking is that they all have a similar architecture. 4). 4 (a) A ribbon representation of the KcsA Kþ channel with its four subunits coloured differently. The channel is orientated with the extracellular solution on top. (b) The KcsA Kþ channel with front and back subunits removed. The pore helices are shown in red and selectivity filter in yellow; the electron density along the ion pathway is shown in a blue mesh. [Reproduced with permission from MacKinnon, R. (2004) Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture).

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