By S. B. Sieczkarski, G. R. Whittaker (auth.), Dr. Mark Marsh (eds.)
The skill of viruses to take advantage of mobile features for his or her personal ends makes them powerful pathogens and beautiful experimental instruments. paintings with viruses underpins a lot of our present figuring out of molecular mobile biology and similar fields. all of the 8 chapters during this quantity offers with a selected point of viral interactions with mobile membranes. those contain chapters on viral access, viral membrane fusion, viral membrane protein synthesis and delivery, viral replication, viral interactions with cytoskeletal structures and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host phone protein trafficking. those chapters may still supply either an outline of mobile membrane trafficking mechanisms and viral interactions with those platforms, in addition to studies of the present nation of every of the fields.
Read Online or Download Membrane Trafficking in Viral Replication PDF
Best viral books
The table Encyclopedia of Microbiology goals to supply a cheap and prepared entry to a wide number of microbiological issues inside one set of covers. this useful desk-top reference brings jointly an exceptional selection of paintings by way of the pinnacle scientists within the box. overlaying subject matters starting from the fundamental technology of microbiology to the present "hot" themes within the box.
This can be virtually a unique booklet (encyclopedia of infectious illnesses geared toward the proverbial 'intelligent layman'), and is strangely demanding to discover at the retail industry. each one affliction access has an advent via sections on indicators and diagnostic direction, treatments and outlook, and possibility components and preventive measures.
Infections of the lung make up an important share of the paintings of the respiration and infectious affliction doctor. Drawing at the illustrative assets of the Edinburgh Royal Infirmary, this superbly awarded atlas presents a visible method of the subject. Dr Hill has chosen various image pictures for you to let the consumer to work out examples of either the infrequent and standard manifestations of those problems.
Revisiting the pondering on vulnerability to HIV and threat of an infection, this e-book presents greater realizing through contemplating the chance of HIV an infection along notions of private and collective resilience, dignity and humiliation.
Additional info for Membrane Trafficking in Viral Replication
B Known class II fusion proteins are activated by proteolytic cleavage of an accessory protein. c The postfusion forms of all known class I fusion proteins are a-helical. The fusion subunit of metastable influenza HA is also highly a-helical, and this appears to be the case for a paramyxovirus F protein [Chen et al. (2001a) Structure 9:255–66]. Comparable information is not available for the metastable forms of other class I fusion proteins. d In the case of paramyxoviruses, the receptor binding protein relays the information of receptor binding to the fusion subunit [Lamb 1993; Colman and Lawrence 2003] followed by an extended chain (Fig.
C-terminal helices are green. For influenza HA2, the C-terminal extended region is yellow. N and C indicate the points where the fusion peptide and the transmembrane domain, respectively, attach ture, a host cell protease cleaves prM, resulting in reorganization of proteins on the viral surface (Allison et al. 1995). After prM cleavage, the E proteins exist as metastable homodimers. The ectodomains of the dimer are oriented antiparallel to one another. In further contrast to the trimeric class I fusion protein spikes, the ectodomains of the E homodimer lie parallel to the viral membrane and close to the surface.
Paramyxovirus F Proteins (Class I Fusion Protein, Neutral pH, Attachment Protein Assisted) . . . . . . . . . . TBE E and SFV E1 (Class II Fusion Proteins, Low pH) . . . . . . . . 36 38 5 Membrane Dynamics During Fusion . . . . . . . . . . 4 Membrane-Interacting Regions of Viral Fusion Proteins. The Fusion Peptide . . . . . . . . . . . Structure of N-terminal Fusion Peptides . . . . . Structure of Internal Fusion Peptides . . . . . . Roles of Fusion Peptides .