Matrix Metalloproteinases in Tissue Remodelling and by Vincent Lagente, Elisabeth Boichot

By Vincent Lagente, Elisabeth Boichot

Matrix metalloproteinases (MMPs) are proteolytic enzymes believed to be keen on many physiological and pathological procedures linked to inflammatory reactions. MMP synthesis and services are regulated through 3 significant mechanisms together with transcriptional activation, post-transcriptional processing, and keep watch over of job by way of tissue inhibitors of metalloproteinases (TIMPs). Many cellphone kinds were pointed out as manufacturers of MMPs and TIMPs in a context of inflammatory methods. MMPs are concerned about a number of inflammatory illnesses, together with breathing, cardiovascular and primary anxious method pathologies. This quantity provides new advances within the involvement of MMPs in a variety of illnesses linked to inflammatory strategies. in addition, the new improvement of selective and non selective inhibitors of MMPs offers new insights within the courting among activation of inflammatory cells and tissue remodelling and advises new healing probabilities for the therapy of inflammatory ailments.

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Am J Respir Cell Mol Biol 16: 212–219 Schwingshackl A, Duszyk M, Brown N, Moqbel R (1999) Human eosinophils release matrix metalloproteinase-9 on stimulation with TNF-alpha. J Allergy Clin Immunol 104: 983–989 Jeong WI, Do SH, Jeong DH, Hong IH, Park JK, Ran KM, Yang HJ, Yuan DW, Kim SB, Cha MS et al (2006) Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat. Anticancer Res 26: 3517–3526 Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, Welgus HG (1991) Human 92- and 72-kilodalton type IV collagenases are elastases.

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On the other hand, MMP-1, 2, 3, 9, 13 and 14 activate CXCL11/SDF 1, while MMP-9 can process CXCL5/ENA 78, CXCL6/GCP 2 to inactivate them, but it increases the activity of IL-8/CXCL8 [85, 86]. MMP9 also is required for transepithelial gradients of CCL11/eotaxin, facilitating the movement of chemokines from one compartment to another [87]. MMP-2-deficient mice demonstrate a reduced degree of allergic inflammation due to decreased levels of CCL11/eotaxin [88]. On the other hand, MMP-12 is required for the influx of macrophages to the lungs of cigarette-smoke exposed lungs [35]; this effect may be indirect through the effect of MMP-12 in generating chemotactic fragments from elastin.

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