Infectious Processes: Knowledge, Discourse, and the Politics by Eve Seguin (eds.)

By Eve Seguin (eds.)

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Oesch, B. et al. (1988) ‘Search for a Scrapie-specific Nucleic Acid: a Progress Report’, Ciba Foundation Symposium 135: 209–23. Parry, H. B. (1962) ‘Scrapie: a Transmissible and Hereditary Disease of Sheep’, Heredity 17: 75–105. Pattison, I. H. (1965) ‘Resistance of the Scrapie Agent to Formalin’, Journal of Comparative Pathology 75: 159–64. Pattison, I. H. (1966a) ‘Experiments with Scrapie with Special Reference to the Nature of the Agent and the Pathology of the Disease’, in D. C. Gajdusek et al.

And Millson, G. C. (1961a) ‘Further Experimental Observations on Scrapie’, Journal of Comparative Pathology and Therapeutics 71: 350–9. Pattison, I. H. and G. C. Millson (1961b) ‘Scrapie Produced Experimentally in Goats with Special Reference to the Clinical Syndrome’, Journal of Comparative Pathology and Therapeutics 71: 101–8. Penrose, L. S. and R. Penrose (1957) ‘A Self-reproducing Analogue’, Nature 179: 1183. Prusiner, S. B. (1982) ‘Novel Proteinaceous Infectious Particles Cause Scrapie’, Science 216: 136–44.

At about the same time Alan Dickinson, later director of the Neuropathogenesis Unit (NPU) in Edinburgh, suggested that the agent might be a virino, that is, a piece of nucleic acid coated with host protein. These opposing views led to a controversy between two groups of TSE researchers. In order to analyse this controversy, I will use a theoretical framework ‘styles of scientific practice’, which is extended from Jonathan Harwood’s work on style. In the course of the controversy, divergent ideas derived not only from actual experimental results, but also from different styles of research programmes determined by different styles of practice.

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