Immunological Aspects of Viral Oncolysis by Professor Jean Lindenmann M.D., Paul A. Klein Ph.D. (auth.)

By Professor Jean Lindenmann M.D., Paul A. Klein Ph.D. (auth.)

mouse tissue alloantigen detected by way of this process. An antigen of cross-reacting specificity was once printed in tissue extracts of many different animal species. We subsequent desired to study extra in regards to the antigen answerable for induction of postoncolytic immunity. Extracts from virus-infected tumors have been immunogenic, and either lively and inactive fractions of such extracts have been received. the expansion of the virus within the tumor cells was once studied with the electron microscope, within the desire that this is able to shed a few gentle at the demeanour within which viral an infection transforms a poorly immunogenic tumor right into a hugely immunogenic one. We examine not one of the questions which our paintings has raised as certainly solved. in reality, we're nonetheless engaged on the various elements alluded to above. once we launched into a research of postoncolytic immunity, we have been supported during this undertaking through our loss of adventure within the fields of transplantation and tumor immunology.

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Sample text

Normal mouse serum from all strains tested failed to precipitate with no. 24 fluid. Whole ICR embryos of 15 days gestation contained the antigen. Table 4 summarizes our findings to date on the distribution of the E antigen in various mouse strains and in some mouse tumors. There is no obvious relationship of the E-antigen to the strong H-2 locus of the mouse. A mice, likewise H-2' and congenic with C57BLl10, contain E. In addition, H-2k is represented in mice which have E (C58/]) and in mice which lack f (CaH).

In the few cytotoxicity tests performed by us, we have failed to detect cytotoxic antibodies in postoncolytic hyperimmune sera. This failure may be due to technical problems inherent in the test although the procedures have been those commonly employed in most laboratories concerned with cytotoxic phenomena (B. BENNETT, personal communication). , 1962) have failed to yield evidence for any cytotoxic activity in postoncolytic immune sera. A good correlation has been shown to exist between cytotoxic sensitivity of normal and neoplastic mouse cells and concentration of alloantigenic receptor sites on the cell surface (MOLLER and MOLLER, 1962).

These results are summarized in Table 2. Thus, the observation that adoptive transfer of postoncolytic immunity was indeed possible, made sum immunity similar to those involving allogeneic tumor grafts (MITCHISON, 1955). Table 2. p. p. v. p. p. p. 17 weeks after transfer) 0/12 a 0/12 0/6 6/6 0/12 0/12 6/6 8/8 8/12 12/12 b 10/10 d a No. of mice dying of ascites / No. of mice in each group. b Mean survival time 22 days. c Pooled serum from spleen cell donors. d Mean survival time 17 days. More surprising than this, however, was our finding that sera from immune animals could confer protection against tumor challenge.

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