Human Papillomavirus: IARC Monographs on the Evaluation of by The International Agency for Research on Cancer

By The International Agency for Research on Cancer

This 90th quantity of the IARC Monographs at the assessment of Carcinogenic dangers to people considers human papillomaviruses (HPVs), that have been evaluated via a prior operating crew (IARC, 1995). The monograph within the current quantity comprises new information that experience develop into to be had up to now decade. HPVs signify the most typical infectious brokers which are transmitted sexually in the course of the global; the foremost danger elements are behaviours linked to sexual intercourse. even though so much infections are asymptomatic and are cleared inside a interval of two years, genital HPV an infection can result in scientific illness, together with anogenital warts, cervical neoplasia, cervical melanoma and different anogenital cancers. the chance for patience of an infection and development of the greater than forty genital HPV forms to grade three cervical intraepithelial neoplasia (CIN3) and melanoma differs largely. continual an infection with carcinogenic HPVs happens in almost all instances of cervical melanoma.

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O’Neill & H. Bartsch (1981) Vol. 5. Some Mycotoxins (IARC Scientific Publications No. 44). Edited by L. Stoloff, M. Castegnaro, P. K. O’Neill & H. Bartsch (1983) Vol. 6. N-Nitroso Compounds (IARC Scientific Publications No. 45). Edited by R. K. O’Neill, G. Eisenbrand, B. Spiegelhalder & H. qxp 30 29/11/2007 16:26 Page 30 IARC MONOGRAPHS VOLUME 90 Vol. 7. Some Volatile Halogenated Hydrocarbons (IARC Scientific Publications No. 68). Edited by L. K. O’Neill (1985) Vol. 8. Some Metals: As, Be, Cd, Cr, Ni, Pb, Se, Zn (IARC Scientific Publications No.

The interest in studies of BPV continues and is mainly based on the ease with which some of the most prevalent BPV types (BPV-1 and -2) can be used in tissue culture studies to study the mechanisms of persistence of the viral genome, as well as the patterns of expression of specific viral genes. Oesophageal carcinomas that originate from BPV-4positive papillomatosis of the oesophagus have added to this interest (Campo, 1987). qxp 29/11/2007 16:28 Page 35 GENERAL REMARKS 35 Moreover, the use of BPV DNA in shuttle vectors and the episomal persistence of this DNA greatly increased the number of studies on these types of virus.

A fourth root of papillomavirus research resulted in the identification of specific HPV types as causative agents for cancer of the cervix, other anogenital cancers and a subset of oropharyngeal carcinomas. These investigations were initiated to investigate a viral etiology of cancer of the cervix. , 1970) were applied to cervical cancer in attempts to detect herpes simplex virus type 2 (HSV 2) DNA in these biopsies. , 1969). The failure to find traces of HSV 2 DNA in these cancer biopsies prompted the search for other potential infectious candidates in the cause of this cancer, since its epidemiology provided good reasons to suspect an infectious etiology (zur Hausen, 1976).

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