Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis by Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski,

By Ann Arvin, Gabriella Campadelli-Fiume, Edward Mocarski, Patrick S. Moore, Bernard Roizman, Richard Whitley, Koichi Yamanishi

This definitive and finished account of the human herpes viruses offers an encyclopedic evaluate in their simple virology and scientific manifestations. This team of viruses contains human simplex kind 1 and a couple of, Epstein Barr virus, cytomegalovirus and varicella-zoster virus. The illnesses they reason are major and infrequently recurrent. Their incidence within the constructed global debts for an incredible burden of ailment, and accordingly there's a good deal of analysis into the pathophysiology if an infection and immunobiology. one other very important zone lined inside of this quantity matters antiviral treatment and the advance of vaccines. a majority of these points are lined extensive and the quantity is absolutely brand new either scientifically and when it comes to scientific guidance for sufferer care. The textual content is generously illustrated all through and completely referenced to the most recent study and advancements.

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Extra resources for Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis

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Beck, S. et al. (1990). Analysis of the protein coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. , 154, 125–169. , and Sheldrick, P. (1979). Physical map of the channel catfish virus genome: location of sites for restric- tion endonucleases EcoRI, HindIII, HpaI and XbaI. J. , 31, 73–85. Clements, J. , and Wilkie, N. M. (1976). Analysis of herpesvirus DNA substructure by means of restriction endonucleases. J. Gen. , 30, 243–256. Coberley, S. , Condit, R.

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In addition, repeats often do not contain protein-coding regions. As elaborated below, certain genomes exhibit a further structural complexity known as segment inversion, in which unique regions flanked by inverted repeats are found in both orientations in virion DNA. Thus, a genome with two such unique regions would produce either two or four isomers depending on whether one or both regions invert. This phenomenon is probably a consequence of recombination between repeats in concatemeric DNA. Isomers are functionally equivalent (Jenkins and Roizman, 1986), and segment inversion appears to be unrelated to the biology of the virus.

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