Epilepsy: Models, Mechanisms and Concepts by Philip A. Schwartzkroin

By Philip A. Schwartzkroin

Advances in epilepsy learn are happening at a speedy fee, leading to a bewildering wealth of knowledge. the results of this new wisdom for destiny examine and medical perform will be complicated. This quantity concentrates at the ideas and types of epilepsy which have been constructed due to this study. Written via admired researchers within the box, it describes and discusses the proper types used to deal with serious questions, and experiences the main updated concerns. Chapters concentrate on the pathways and mechanisms by which seizure job is initiated and unfold, in either general and irregular mind tissues, and speak about the designated houses of epileptogenesis within the immature mind. In a box within which fast advances result in consistent replace of empirical information, this booklet takes a conceptual method of the topic and offers an outstanding framework during which to appreciate the rising matters.

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The epileptogenic process gives us an opportunity to investigate what factors are critical in inducing a relatively normal brain to become abnormal. Several key factors have been identified. The site at which stimulation occurs (or drug is injected, as in chemical kindling) is clearly of significance (Racine, 1978). Regions of the limbic system tend to be especially sensitive; that is, the fully kindled state is achieved with relatively fewer stimulations in these structures than in neocortical sites.

Given the fragmentary information available, such questions are probably best studied with several recently developed models of inducing The kindling model of epilepsy 37 seizures in hippocampal slices in vitro; the model of stimulus-traininduced seizures (Stasheff et al, 1989; Chapter 11, this volume) in hippocampal slices seems especially well suited to address questions related to epileptic seizures. The anatomical network of kindling Limited insight into the precise anatomical distribution of the brain nuclei containing the abnormal hyperexcitability or responsible for its development hampers investigation of the mechanisms.

A regional increase in the number of hippocampal GABAergic neurons and terminals in the seizure-sensitive gerbil. Brain Research, 340: 384-9. Pierson, M. G. & Swann, J. (1991). Ontogenetic features of audiogenic seizure susceptibility induced in immature rats by noise. Epilepsia, 32: 1-9. 26 Chronic models in intact animals Pinel, J. P. J. & Rovner, L. I. (1978). Electrode placement and kindling-induced experimental epilepsy. Experimental Neurology, 58: 335-46. Piredda, S. & Gale, K. (1985). A crucial epileptogenic site in the deep prepiriform cortex.

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