Dopamine and Glutamate in Psychiatric Disorders by Werner Schmidt, Maarten E. A. Reith

By Werner Schmidt, Maarten E. A. Reith

An illuminating precis of our present realizing of the interactive position of dopamine and glutamate in psychiatric illnesses and the healing suggestions and probabilities for destiny remedy. one of the new principles offered are hypotheses at the position of dopamine and glutamate in aggression, the glutamate procedure in anxiousness issues, glutamate and neurodegeneration, and at the beginning and development of Parkinson's ailment. extra chapters provide novel insights right into a number of psychiatric illnesses, together with ADHD, rigidity, aggression, habit, schizophrenia, melancholy, social phobias, dementias, bulimia, and neurodegenerative ailments like Parkinson's and Alzheimer's illnesses. each one bankruptcy summarizes the superiority and signs of the ailment and explains the involvement of dopamine and/or glutamate platforms utilizing the more recent molecular methods comparable to transgenic knockout or knockin mice and up to date mind imaging innovations.

Show description

Read Online or Download Dopamine and Glutamate in Psychiatric Disorders PDF

Best neurology books


Have you obvious whatever that wasn't relatively there? Heard somebody name your identify in an empty residence? Sensed a person following you and rotated to discover nothing?

Hallucinations don’t belong entirely to the insane. even more in general, they're associated with sensory deprivation, intoxication, disease, or damage. individuals with migraines may even see shimmering arcs of sunshine or tiny, Lilliputian figures of animals and other people. individuals with failing eyesight, ironically, may perhaps develop into immersed in a hallucinatory visible global. Hallucinations could be caused by an easy fever or maybe the act of waking or falling asleep, whilst humans have visions starting from luminous blobs of colour to fantastically unique faces or terrifying ogres. people who are bereaved may possibly obtain comforting “visits” from the departed. In a few stipulations, hallucinations can result in non secular epiphanies or perhaps the sensation of leaving one’s personal physique.

Humans have regularly sought such life-changing visions, and for hundreds of thousands of years have used hallucinogenic compounds to accomplish them. As a tender health care provider in California within the Nineteen Sixties, Oliver Sacks had either a private and a pro curiosity in psychedelics. those, with his early migraine studies, introduced a lifelong research into the forms of hallucinatory adventure.

Here, together with his traditional beauty, interest, and compassion, Dr. Sacks weaves jointly tales of his sufferers and of his personal mind-altering reviews to light up what hallucinations let us know concerning the association and constitution of our brains, how they've got inspired each culture’s folklore and paintings, and why the opportunity of hallucination is found in us all, an essential component of the human .

Paediatric Neurology in Clinical General Practice: Common Neurological Problems in General Pediatrics

The overall pediatrician faces an array of medical conditions in scientific perform. This quantity is meant to relieve questions about one quarter the overall pediatrician faces: universal neurological difficulties. Emphasizing the problems that one of these practitioner may well face in daily perform, instead of infrequent or strange stipulations, this e-book describes the way to continue with the medical exam, analysis and administration of neurological difficulties in little ones.

Extra info for Dopamine and Glutamate in Psychiatric Disorders

Example text

Ariano MA. Distribution of dopamine receptors. In: Neve KA, Neve RL, ed. The Dopamine Receptors. Totawa, NJ: Humana Press, 1997:77–103. 39. Van Tol HHM, Bunzow JR, Guan H-C, et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991; 350:610–614. 40. Sunahara RK, Guan H-C, O’Dowd BF, et al. Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature 1991; 350:614–619. Dopamine Receptors 27 41.

J Biol Chem 1996; 271:3771–3778. 76. Mason JN, Kozell LB, Neve KA. Regulation of dopamine D1 receptor trafficking by protein kinase A-dependent phosphorylation. Mol Pharmacol 2002; 61:806–816. 77. Lamey M, Thompson M, Varghese G, Chi H, Sawzdargo M, George SR, et al. Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor. J Biol Chem 2002; 277:9415–9421. 78. Kim KM, Valenzano KJ, Robinson SR, Yao WD, Barak LS, Caron MG.

145. Cole RL, Konradi C, Douglass J, Hyman SE. Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. Neuron 1995; 14:813–823. 146. Liu FC, Graybiel AM. Spatiotemporal dynamics of CREB phosphorylation: transient versus sustained phosphorylation in the developing striatum. Neuron 1996; 17:1133–1144. 147. Snyder GL, Fienberg AA, Huganir RL, Greengard P. A dopamine D1 receptor protein kinase A dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa) protein phosphatase1 pathway regulates dephosphorylation of the NMDA receptor.

Download PDF sample

Rated 4.89 of 5 – based on 14 votes