Dengue by Scott B. Halstead

By Scott B. Halstead

This distinct quantity provides an updated overview of 1 of the area s significant illnesses -- ailments because of the 4 dengue viruses. It starts off with an insightful tale of the foundation of dengue sickness outbreaks, together with the emergence of critical and deadly dengue hemorrhagic fever. The nature, constitution and biology of the 4 dengue viruses are defined, and a significant element of the e-book is targeted at the epidemiology of dengue as a mosquito-borne affliction. this is often complemented by way of evaluations of current mosquito regulate courses by way of 3 teams of exceptional specialists. The most powerful part of the quantity is its finished description of the present knowing of dengue illness pathogenesis, by way of an research of the execs and cons of 5 of the main arguable components within the box: the WHO DEF case definition, secondary dengue infections, virulent viruses, the function of irregular T cells and autoimmunity.

Contents: Dengue: evaluation and heritage (S B Halstead); The Infectious Agent (D W C Beasley & A D T Barrett); Epidemiology (S B Halstead); Resistance to an infection (D W Vaughn et al.); scientific beneficial properties of Dengue (J Farrar); administration of Dengue (B Wills); Pathogenesis: probability elements sooner than an infection (S B Halstead); removing of an infection (A L Rothman & F A Ennis); Pathophysiology (S B Halstead); prognosis of Dengue Virus Infections (T P Endy et al.); The keep watch over of Dengue Vectors (N G Gratz & S B Halstead); organic keep watch over of Dengue Vectors: gives you from the earlier (B H Kay); Mosquito regulate: Behavioral and group Interventions (P Winch et al.); Controversies (J Rigau-Perez et al.).

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Sample text

Although genotypes have been reported, each flavivirus exists as a single serotype. Nucleotide sequences for portions of most flaviviruses can be found in Genbank. Dengue serogroup These viruses are often described as four serotypes of the dengue virus. However, this nomenclature is somewhat misleading, as the four dengue viruses are antigenically and genetically distinct rather than being four serotypes of the same virus as exemplified by the three serotypes of the poliovirus. It is more accurate to consider the dengue viruses as four related viruses that cause very similar disease in humans.

T. 1 substitutions/site Fig. 1. Neighbor-joining tree compiled with whole genome sequences of flaviviruses available in the Genbank database using a Kimura two-parameter distance formula. , MD) and phylogenetic analysis with PAUP. qxd 9/16/2008 12:26 PM Page 33 The Infectious Agent 33 Immature virion Mature virion E E dimer prM Nucleocapsid M Fig. 2. Schematic diagram of the structure of immature (cell-associated) and mature flavivirus virions. Modified from Ref. 186. 9 As a result of this arrangement, the immature virion was slightly larger (~ 60 nm diameter) than the mature particle.

The term “flaviviruses” is generally considered to be restricted to the Flavivirus genus. Yellow fever virus (YFV) is the prototype member of the Flavivirus genus. On the basis of their ecology, flaviviruses have been termed “arboviruses” or arthropod-borne viruses to denote the fact that many are transmitted between vertebrate hosts by mosquitoes or ticks. It should be noted that other families of viruses are also termed “arboviruses,” including members of Togaviridae, Bunyaviridae, Reoviridae, Orthomyxoviridae and Rhabdoviridae.

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