Concepts in Viral Pathogenesis by G. John Stanton, S. Baron (auth.), Abner Louis Notkins M.D.,

By G. John Stanton, S. Baron (auth.), Abner Louis Notkins M.D., Michael B. A. Oldstone M.D. (eds.)

The present proliferation of clinical info makes it tough for even the main diligent reader to take care of with the most recent advancements in his/her personal box, not to mention different components of curiosity. overview articles are one answer, yet they too became so voluminous and targeted that they typically defeat the aim for which they have been meant. we have now tried to ease this challenge by utilizing a special structure. during this quantity on thoughts in Viral Pathogenesis, we've got assembled a sequence of mini-reviews/editorials, 1,000 to 2,000 phrases in size. each one is a pithy distil­ lation of the cutting-edge with emphasis on present pondering and unifying innovations instead of a compendium of the literature. The fifty three articles, all written through lively employees of their respective fields, are prepared systemati­ cally in order that the publication will supply busy investigators, lecturers and scholars of updated info in a really short and simply learn­ a conceptual center capable shape. furthermore, the authors have tried to spot unresolved difficulties and aspect to destiny directions.

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Virology 68:426-439 19. Lazarowitz SG, Choppin PW (1975) Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide. Virology 68:440-454 20. Garten W, Bosch FX, Linder D, Rott R, Klenk H-D (1981). Proteolytic activation of the influenza virus hemagglutinin: The structure of the cleavage site and the enzyme involved in cleavage. Virology 115:361-374 Proteolytic Cleavage and Virus Pathogenesis 31 21. Huang RTC, Rott R, Klenk H-D (1981) Influenza viruses cause hemolysis and fusion of cell.

Sindbis virus activates either the classical or alternative pathways in the absence of antibody [9] while Newcastle disease virus can be neutralized via the classical pathway without antibody participation [10]. Epstein-Barr virus directly activates the alternative pathway [11]. Although relatively few viruses have been examined as yet, it is likely, based on the above examples and the many structurally different types of nonviral substances that activate the classical and alternative pathways in the absence of antibody, that further study will reveal that numerous viruses directly activate one or the other of the complement pathways.

Cooper NR, Jensen FC, Welsh Jr. RM, Oldstone MBA (1976) Lysis of RNA tumor viruses by human serum: Direct antibody independent triggering of the classical complement pathway. J Exp Med 144:970-984 8. Bartholomew RM, Esser AF, Muller-Eberhard HJ (1978) Lysis of oncornaviruses by human serum: Isolation of the viral complement (C I) receptor and identification as p15E. J Exp Med 147:844-853 9. Hirsch RL, Winkel stein JA, Griffin DE (1980) The role of complement in viral infections. J lmmunol 124:2507-2510 10.

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