Comprehensive Management of Arteriovenous Malformations of by Robert F. Spetzler, Douglas S. Kondziolka, Randall T.

By Robert F. Spetzler, Douglas S. Kondziolka, Randall T. Higashida, M. Yashar S. Kalani

Vascular malformations of the mind and backbone pose many administration demanding situations. this article presents a entire, state of the art assessment of the typical background, cures, and results of sufferers with those stipulations. regardless of their relative rarity, those lesions are chargeable for devastating harm to participants and will reason an everlasting actual, mental, and financial burden on sufferers and households. Many new healing suggestions at the moment are to be had with the arrival of novel surgical, endovascular, and radiosurgical options. the fundamental sciences have fuelled improvement of small molecule and biologic treatments focusing on the molecular foundation of illness. Authored through overseas specialists within the fields of neurosurgery, neurology, radiology, and radiation oncology, this publication offers state of the art healing procedures and discussions of excellent remedy. this article is geared toward practitioners within the fields of neurology, neurosurgery, neuroradiology, radiation oncology, rehabilitation drugs and allied fields who deal with sufferers with mind and spinal vascular malformations.

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Arterioscler Thromb Vasc Biol 2012;32:196–206. 131. Helgadottir A, Thorleifsson G, Magnusson KP, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008;40:217–24. 139. Weinsheimer S, Pawlikowska L, Xu H. Integration of genome-wide SNP and expression profiling data to identify candidate genes for brain arteriovenous malformation hemorrhage. In American Society of Human Genetics 59th Annual Meeting Honolulu, 2009.

The anterior choroidal artery, which may be a single vessel or a plexus of small vessels, arises from the posterior medial C7 segment superior to the posterior communicating artery. There are two branches of the anterior choroidal artery, cisternal and intraventricular. The cisternal branch courses posteromedially within the crural cistern around the cerebral peduncle towards the lateral geniculate body of the thalamus, turning sharply medially to enter the temporal horn through the choroidal fissure.

This artery is significant for two reasons: first, it supplies cranial nerves III, IV, and VI, the Gasserion ganglion, and the cavernous sinus dura; second it forms external carotid artery (ECA) to ICA (ECA–ICA) collaterals via the artery of foramen rotundum with the internal maxillary artery and via posterior branches with the middle meningeal artery and maxillary artery. The least consistent of the C4 segment branches is the capsular artery of McConnell, which is seen in 28% of individuals and supplies the pituitary gland.

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