Comorbidity in Migraine by Jean Schoenen, David W. Dodick, Peter S?ndor

By Jean Schoenen, David W. Dodick, Peter S?ndor

This e-book provides a clinically orientated method of figuring out and treating co-morbid migraine. Case vignettes and administration algorithms will improve the scientific application of the booklet.

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Extra resources for Comorbidity in Migraine

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57 Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE. Migraine. vascular risk, and cardiovascular disease in women. Prospective cohort study. a636. 58 Lee ST, Chu K, Jung KH, et al. Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 2008;70:1510–17. 59 Kunz GA, Liang G, Cuculi F, et al. Circulating endothelial progenitor cells predict coronary artery disease severity. Am Heart J 2006;152:190–5. 60 Vanmolkot FH, Van Bortel LM, de Hoon JN. Altered arterial function in migraine of recent onset.

Indd 31 1/31/2011 1:04:21 PM 32 Comorbidity in Migraine In observational studies, therefore, the expectation is that migraineurs who are prescribed triptans would be at reduced risk of CVD compared to migraineurs who are not prescribed triptans. Observational studies that compare cardiovascular outcomes in triptan-using versus non-triptan-using migraineurs are thus inherently confounded by indication in a way that would be expected to attenuate or reverse any theoretical increased risk of cardiovascular disease in migraineurs; adjustment for known risk profiles can only partly control for this inherent limitation.

Sándor. © 2011 Blackwell Publishing Ltd. Published 2011 by Blackwell Publishing Ltd. 1 Risk of non-stroke cardiovascular disease from non-clinical populations. Mig or MA Author Source Study subjects Age Risk or odds of CHD in migraineurs vs non-migraineurs [95% CI] CHD outcome Prospective cohort studies MA Gudmundsson et al. 2010 [8] Kurth et al. 5] Mig‡ Kurth et al. 3] MA§ Liew et al. 8] (♀) No CHD deaths (♂) MA** Rose et al. 2004 [13] Blue Mountain Eye Study ARIC – community Coronary revascularization Myocardial infarction Angina Coronary revascularization Myocardial infarction Angina CHD death 12,409 45–64 Fatal/non-fatal CHD Rose angina Mig†† Sternfeld et al.

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