Cardiovascular Risk Factor Management in the Prevention of by P. Amarenco

By P. Amarenco

Amassed listed below are the findings of the satellite tv for pc symposium hung on the social gathering of the eleventh eu Stroke convention.

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045) in this highly unstable and high-risk population [25]. The results of MIRACL suggest that patients with acute coronary syndromes should begin to receive statin treatment before leaving hospital in order to expedite the stabilisation process. population at very high risk of CHD. The fact that patients with the metabolic syndrome, as well as those with LDL cholesterol, are amenable to lipid-lowering therapy is supported by the Veterans Affairs HDL Intervention Trial (VA-HIT) and Diabetes Atorvastatin Lipid Intervention (DALI) studies with gemfibrozil and atorvastatin, respectively, both of which enrolled patients with high triglyceride and low HDL cholesterol levels [28, 29].

The Atorvastatin and Simvastatin on Atherosclerosis Progression (ASAP) trial was designed to assess the effect of aggressive lipid lowering versus moderate lipid lowering on the progression of atherosclerosis. LDL cholesterol lowering with atorvastatin 80 mg/day was accompanied by significant regression in carotid IMT in patients with familial hypercholesterolaemia, whereas moderate lipid lowering with simvastatin 40 mg was not [31] (fig. 4). The ASAP trial is important as the regression in carotid IMT associated with aggressive atorvastatin therapy may result in a significant reduction in cardiovascular events, and in 30 Cerebrovasc Dis 2003;16(suppl 3):25–32 younger adults may ameliorate the atherosclerotic process before the development of symptomatic disease.

16 Lammie GA, Sandercock PA, Dennis MS: Recently occluded intracranial and extracranial carotid arteries. Relevance of the unstable atherosclerotic plaque. Stroke 1999;30:1319– 1325. 17 Rost NS, Wolf PA, Kase CS, Kelly-Hayes M, Silbershatz H, Massaro JM, D’Agostino RB, Franzblau C, Wilson PW: Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study. Stroke 2001;32:2575–2579. 18 Nesto RW, Rutter MK: Impact of the atherosclerotic process in patients with diabetes.

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