Carcinogenicity of Inorganic Substances. Risks from by J H Duffus

By J H Duffus

Specializes in the nation of clinical wisdom in regards to the carcinogenicity of metals, their compounds and different inorganic components. It presents a priceless consultant for chemists interested by hazard evaluation, well-being and protection and toxicology

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Whether or not cancer results is perhaps happen-stance. 5 Transition Metals Groups 5 to 11 These are the familiar heavier elements in three rows, see Figure 1, and I shall stay with the first row for much of my discussion, since the elements are often biologically essential. The elements are: V, Cr, Mn, Fe, Co, Ni, Cu We have already noted that, in man, Ni as N i is removed by separation into vesicles. We can add that Cr as C r is also avoided perhaps for the same reason as that proposed for avoiding all other M ions.

16 3 Carcinogenicity of Fibrous Particles The hypothesis that morphology is the single most important determinant of the carcinogenic activity of fibrous particles is often referred to as the Stanton Hypothesis. 25 |im or less in diameter and more than 8 \im in length. These narrow, fibrous particles of course have the greatest surface area and particle number per unit mass of dust. The experimental data, which form the basis of the hypothesis, were obtained in a model where tumors were induced after the surgical implantation of a thin pledget of coarse fibrous glass (30mm x 30mm x 2 mm, weighing about 45 mg and coated on one side with the fibre to be evaluated) into the pleura of the animal.

The ratio of length to width is referred to as the aspect ratio. A fibre population will contain a distribution of fibres of various lengths and diameters. Often only these two dimensions are used to describe three dimensional fibres due to assuming a particular cross-sectional configuration. The crosssectional configuration of the fibres can be variable and difficult to determine, therefore they are not often described. The extent of the variation in surface area and particle number per unit mass of the dust will be calculated for various fibre width, densities and cross-sectional configurations of the idealized fibre.

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