Biomarkers for early diagnosis of Alzheimer's disease by Daniela Galimberti

By Daniela Galimberti

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FMRI has advantages in spatial and temporal resolution when compared to the PET technique, and, in addition, the fact that no radionuclides are used makes it feasible to repeat experiments several times on the same subject. However, fMRI imaging has some limits. The main limit is that MRI does not allow molecular imaging, as compared with Emission Tomography techniques. , 2002). Currently, fMRI activation studies are mostly used to gain a better understanding of the neuronal networks involved in specific tasks in the healthy human brain.

E. neuroleptics). For example, dopadecarboxylase enzymatic activity can be measured by 18F-DOPA, acetylcholinesterase activity by 11C-MP4A, post-synaptic dopamine receptor density by 11C-raclopride, and presynaptic dopamine activity by 11CFECIT. e. regional cerebral blood flow, neurotransmission parameters) are examined. SPECT imaging, however, has a lower spatial resolution, a lower signal-to-noise ratio, and 123 Iodine or 99mTechnetium, the most commonly used isotopes, have a longer half-life and have a structure which is likely to change the ligand’s chemical properties.

1938). Concrete model and abstract copy: a psychobiological interpretation of the ‘closing-in’ symptom of Mayer Gross. Journal of Nervous and Mental Disease, 88, 1-11. [35] Gainotti, G. (1972). A quantitative study of the “closing-in” symptom in normal children and in brain-damaged patients. Neuropsychologia, 10, 1429-1436. , Poletti, B. (2005). Closing-in as an Alzheimer disease neuropsychological marker: sensitivity and specificity. Atti della VIII Riunione Scientifica ITINAD (Italian Interdisciplinary Network on Alzheimer Disease), Sorrento 26-28 maggio.

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