Antiviral Drug Discovery for Emerging Diseases and by Paul F. Torrence

By Paul F. Torrence

Antiviral Drug Discovery supplies readers a state-of-the-art view of ways chemical innovations are being mobilized to advance novel methods that may successfully confront rising illnesses and biowarfare. among the themes mentioned are smallpox, the Ebola virus, influenza, SARS, arenaviruses and flaviviruses. each one bankruptcy discusses hypothetical techniques for the invention of appropriate antiviral brokers, contemporary findings with regards to biochemistry or drug discovery, and advances within the additional improvement of tested leads within the sector. well timed and informative, this e-book sincerely delineates the efforts being made to strengthen new and potent broad-spectrum antiviral brokers.

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Shtm General Services Administration. shtml Health Sciences Library System. edu/guides/internet/terror Henry L. html Public Broadcasting System. se/cbw/ St. Louis University. edu/colleges/sph/bioterrorism/ Stimson Center Report No. S. S. Department of State. 1 INTRODUCTION Emerging pathogens and the threat of bioterrorism are inherent elements of modern civilization. A variety of activities, including the expansion of human populations into new geographical areas, may result in contact with novel microbes and their rapid distribution by global transportation systems.

Agents Chemother. 2003, 47, 2933–2937. 33. Kern, E. ; Beadle, J. ; Hostetler, K. Y. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir. Antimicrob. Agents Chemother. 2002, 46, 991–995. 34. ; Wan, W. ; Beadle, J. ; Aldern, K. ; Painter, G. ; Hostetler, K. Y. Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney. Antiviral Res. 2003, 59,163–171. 35. Bray. ; Huggins, J.

CDV increased the mean day of death in SCID mice but could not protect them from mortality when treatment was discontinued. SKH-1 hairless mice (immunocompetent or immunosuppressed) readily became infected with either vaccinia or cowpox when virus was applied to abraded skin. 162,163 Huggins and co-workers reported that cynomolgus monkeys infected with monkeypox either by small-particle aerosol or by intravenous inoculation developed classical poxvirus lesions and pulmonary distress, while one model using intravenous variola produced a similar lesional disease and 33% mortality.

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