Aids-Associated Viral Oncogenesis by Charles Wood Ph.D. (auth.), C. Meyers (eds.)

By Charles Wood Ph.D. (auth.), C. Meyers (eds.)

AIDS-associated viral oncology is an important healthcare challenge. because the id of human immunodeficiency virus (HIV)-associated obtained immune affliction syndrome (AIDS), the function of viruses in human cancers has develop into acutely obvious over the last two decades. the certainty and therapy of AIDS-associated cancers has develop into a huge predicament between healthcare corporations. Human cancers that have been as soon as infrequent within the inhabitants have now develop into universal in the HIV contaminated inhabitants.

Experts proportion their collective wisdom and consider the scientific and organic facets, together with viruses good tested of their roles, in addition to rising new viruses. This quantity should be a source for either individuals of the medical and healthcare group and lively researchers during this field.

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"Human immunodeficiency virus (HIV) - linked got immune sickness syndrome (AIDS) areas contributors at elevated danger for virally mediated cancers. this article addresses the scientific and organic points of this subject. extraordinary investigators within the box current a entire review with relevance to laboratory scientists and practising clinicians."

Steven T. Rosen, M.D.

Series Editor

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226 42 AIDS-Associated Viral Oncogenesis Antiviral Therapy Inconsistent results have been reported in various studies from the use of antiviral therapy targeting HHV-8. For instance, remission of HIV-associated MCD, along with a decline in plasma HHV-8 DNA levels, was attained in three patients treated with intravenous ganciclovir therapy. Two patients, only one on HAART, achieved a reduction in the frequency of recurrent flares of MCD and detectable HHV-8 DNA with intravenous or oral ganciclovir.

In addition,The Swiss cohort study76 with 6,636 HIV-infected individuals found the incidence of systemic NHL post-HAART to be 4 cases/1,000 p-y. 2. AIDS Malignancies 29 However, other studies found nonsignificant increases in AIDS-related NHL incidence. 2). 5 cases/1,000 p-y post-HAART (p-value not significant). 86,87 The IPI includes clinical features that reflect the growth and invasive potential of the tumor (tumor stage, serum LDH level, and number of extranodal disease sites), the patient’s response to the tumor (performance status), and the patient’s ability to tolerate Table 3.

In fact, the unique epidemiology of KS subsequently led to the identification of the novel human herpes virus, HHV-8. Other oncogenic viruses that are linked to HIV-associated malignancies include Epstein-Barr virus (EBV) and human papillomavirus (HPV). These three viruses have now been linked to other HIVassociated malignancies, including Hodgkin’s lymphoma (HL), leiomyosarcoma, multicentric Castleman’s disease (MCD), primary effusion lymphoma (PEL), and anal cancer. The introduction of highly active antiretroviral therapy (HAART) in the 1990s has enormously impacted the outcomes of HIV infection.

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