Adenoviral Vectors for Gene Therapy, Second Edition by David T. Curiel

By David T. Curiel

Adenoviral Vectors for Gene treatment, moment Edition presents exact, complete insurance of the gene supply automobiles which are in line with the adenovirus that's rising as a tremendous instrument in gene treatment. those fascinating new healing brokers have nice strength for the therapy of disorder, making gene treatment a fast-growing box for examine.

This booklet provides issues starting from the fundamental biology of adenoviruses, throughout the building and purification of adenoviral vectors, state of the art vectorology, and using adenoviral vectors in preclinical animal versions, with ultimate attention of the regulatory matters surrounding human medical gene remedy trials. This extensive scope of data offers a pretty good assessment of the sector, permitting the reader to realize a whole knowing of the advance and use of adenoviral vectors.

  • Provides entire assurance of the elemental biology of adenoviruses, in addition to their development, propagation, and purification of adenoviral vectors
  • Introduces universal innovations for the advance of adenoviral vectors, besides state of the art equipment for his or her improvement
  • Demonstrates noninvasive imaging of adenovirus-mediated gene transfer
  • Discusses software of adenoviral vectors in animal illness models
  • Considers Federal Drug management laws for human scientific trials

Show description

Read Online or Download Adenoviral Vectors for Gene Therapy, Second Edition PDF

Similar viral books

The Desk Encyclopedia of Microbiology

The table Encyclopedia of Microbiology goals to supply a cheap and prepared entry to a wide number of microbiological issues inside one set of covers. this convenient desk-top reference brings jointly a good choice of paintings by way of the pinnacle scientists within the box. masking issues starting from the elemental technology of microbiology to the present "hot" subject matters within the box.

Encyclopedia of infectious diseases

This is often virtually a special e-book (encyclopedia of infectious illnesses geared toward the proverbial 'intelligent layman'), and is unusually challenging to discover at the retail industry. every one ailment access has an creation via sections on signs and diagnostic direction, cures and outlook, and probability components and preventive measures.

Pulmonary Infection: An Atlas of Investigation and Management

Infections of the lung make up an important share of the paintings of the breathing and infectious disorder healthcare professional. Drawing at the illustrative assets of the Edinburgh Royal Infirmary, this superbly offered atlas offers a visible method of the subject. Dr Hill has chosen more than a few photograph photographs so as to allow the person to work out examples of either the infrequent and standard manifestations of those issues.

HIV and Young People: Risk and Resilience in the Urban Slum

Revisiting the pondering on vulnerability to HIV and possibility of an infection, this publication offers greater knowing by means of contemplating the danger of HIV an infection along notions of non-public and collective resilience, dignity and humiliation.

Additional info for Adenoviral Vectors for Gene Therapy, Second Edition

Sample text

Biochim Biophys Acta 2003;1648:1–11. Baniecki ML, McGrath WJ, Mangel WF. Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: III. Atomic resolution structure of the nascent form of the adenovirus proteinase. J Biol Chem 2013;288:2081–91. Rawlings ND, Barrett AJ. Families of cysteine peptidases. Methods Enzymol 1994;244:461–86. Tihanyi K, Bourbonniere M, Houde A, Rancourt C, Weber JM. Isolation and properties of adenovirus type 2 proteinase. J Biol Chem 1993;268:1780–5.

55 Further investigations are required to elucidate the physiological roles of SR and other attachment factors in natural and therapeutic infections of model organisms and humans. 132 They are located on the basolateral side of polarized epithelia but can be relocated apically in the context of infection. Integrins are in a dynamic equilibrium between active ligand-bound and inactive ligand-free states. 134 Integrins occur as 24 α/β heterodimers of 18 α and 8 β subunits. 8 Extracellular Factors Influencing Viral Tropism Body fluids contain factors that bind to AdVs, confer alternative viral tropism, and influence the outcome of both natural infection and systemic gene therapy.

8 Extracellular Factors Influencing Viral Tropism Body fluids contain factors that bind to AdVs, confer alternative viral tropism, and influence the outcome of both natural infection and systemic gene therapy. For example, dipalmitoylphosphatidylcholine (DPPC) in lung surfactant or lactoferrin (Lf) in secretory fluids apparently enhance infection of polarized cells regardless of CAR availability. 145 For example, FX shields circulating viruses from immunoglobulin (Ig) M and complement-mediated neutralization and influences virus liver tropism.

Download PDF sample

Rated 4.11 of 5 – based on 39 votes