50 studies every neurologist should know by David Y. Hwang

By David Y. Hwang

50 reviews each Neurologist may still Know offers key experiences that form the present medical perform of neurology. All neurologic subspecialties are coated, with a distinct emphasis on neurocritical care and vascular neurology. for every examine, a concise precis is gifted with an emphasis at the effects and boundaries of the learn, and its implications for perform. An illustrative medical case concludes each one overview, through short details on different correct experiences. this is often the 1st e-book of its variety to offer a set of the main influential medical trials in neurology which are unique sufficient for use on rounds, yet nonetheless simply digestible. it's a must-read for health and wellbeing care execs and somebody who desires to examine extra concerning the information in the back of medical practice.

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Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56(9):1154–​1166. , et al. Donepezil and memantine for moderate-​to-​severe Alzheimer’s disease. N Engl J Med. 2012;366(10):893–​903. The MMSE scores for inclusion here were 5–​13. Multiple types of cholinesterase inhibitors were included (donepezil, rivastigmine, galantamine) and, as noted, the MMSE range included both moderate and mild AD (memantine has not shown benefit for the mild group in multiple studies).

RESULTS • The median duration of headache before initiation of treatment was 425 minutes in the 6 mg sumatriptan group, 421 minutes in the 8 mg group, and 357 minutes in the placebo group. 001). 1). 001). • Sumatriptan was significantly more effective than placebo in relieving nausea, vomiting, photophobia, and phonophobia. • Treatment with sumatriptan markedly improved ability to function normally: at 60 minutes, 45% could function normally compared with 9% treated with placebo; at 120 minutes, the numbers were 78% versus 22%.

Lamotrigine is not inferior to carbamazepine in time to treatment failure as defined by inadequate seizure control. The most common clinically important adverse events reported in the trial for carbamazepine was tiredness, drowsiness, fatigue, and lethargy (36/​378 per protocol for CBZ, 17/​378 for LTG). There is hence evidence to support starting LTG as initial monotherapy for good efficacy and better tolerability. Alternately, controlled-​release CBZ or the newer agents LEV or ZNS could also be considered, given level A recommendations by the latest ILAE guidelines.

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